Acromegaly disease activity according to ACRODAT®, a cross-sectional study in Spain: ACROVAL study

Abstract

Objectives: To evaluate disease activity status using the Acromegaly Disease Activity Tool (ACRODAT^®) in a cohort of Spanish acromegaly patients, to assess the relationship between the level of disease activity according to both ACRODAT^® and the physicians' clinical evaluation, and to study the potential discrepancies in the perception of symptoms between physicians and patients.

Design: Multicenter, observational, descriptive and cross-sectional study.

Methods: Disease activity was assessed in adult patients with acromegaly under pharmacological treatment during at least 6 months using ACRODAT^®.

Results: According to ACRODAT^®, 48.2%, 31.8% and 20.0% of a total of 111 patients were classified as having a stable disease (S), mild disease activity (M-DA) and significant disease activity (S-DA) respectively. ACRODAT^® classification of disease activity significantly correlated with physicians' opinion, with a moderate inter-rater agreement and a specificity of 92.45% (PPV = 86.21%). No correlation was found between IGF-I levels and severity of symptoms or quality of life (QoL). A decision to take clinical action was significantly more frequent in S-DA and M-DA patients than S patients but no action was taken on 5 (22.7%) and 27 (77.1%) S-DA and M-DA patients, respectively CONCLUSIONS: ACRODAT^® detected disease activity in 51.8% of patients. Interestingly, although M-DA and S-DA patients were likely to be in the process of being controlled, action was not always taken on these patients. ACRODAT^® is a validated and highly specific tool that may be useful to routinely monitor acromegaly and to identify patients with non-obvious disease activity by incorporating "patient-centred" parameters like symptoms and QoL to the clinical evaluation of acromegaly.

Keywords: ACRODAT®; AcroQoL; Acromegaly; Disease Activity; IGF-I; PASQ; Quality of life.