Abstract
Three undescribed hydroxycinnamic acid amide dimers 1-3 were isolated and identified from an extract of Goji berry. Their molecular structures were elucidated based on NMR, MS, and IR spectra analysis. Compounds 1-3 were hydroxycinnamic acid amide dimers, which possess a cyclic butane moiety formed by head-to-head connection. These compounds at 25 μM showed the disaggregation potency on the copper-mediated Aβ1-42 aggregation ranging from 27.3±3.2 to 31.0±2.9 %. This study provides new information on the antiaging traditional usage of goji berry.
Keywords:
Goji berry; anti-AD activity; hydroxycinnamic acid amide dimer.
© 2021 Wiley-VHCA AG, Zurich, Switzerland.
MeSH terms
-
Alzheimer Disease / drug therapy*
-
Alzheimer Disease / metabolism
-
Amides / chemistry
-
Amides / isolation & purification
-
Amides / pharmacology*
-
Amyloid beta-Peptides / antagonists & inhibitors
-
Amyloid beta-Peptides / metabolism
-
Coumaric Acids / chemistry
-
Coumaric Acids / isolation & purification
-
Coumaric Acids / pharmacology*
-
Dose-Response Relationship, Drug
-
Humans
-
Lycium / chemistry*
-
Molecular Conformation
-
Neuroprotective Agents / chemistry
-
Neuroprotective Agents / isolation & purification
-
Neuroprotective Agents / pharmacology*
-
Peptide Fragments / antagonists & inhibitors
-
Peptide Fragments / metabolism
-
Plant Extracts / chemistry
-
Plant Extracts / isolation & purification
-
Plant Extracts / pharmacology*
-
Protein Aggregates / drug effects
Substances
-
Amides
-
Amyloid beta-Peptides
-
Coumaric Acids
-
Neuroprotective Agents
-
Peptide Fragments
-
Plant Extracts
-
Protein Aggregates
-
amyloid beta-protein (1-42)