Relative children's lipid accumulation with hypertension in Chinese children and adolescents

Abstract

Background: This study aimed to develop a novel indicator associated with hypertension in Chinese children and adolescents, the relative children's lipid accumulation product (RCLAP).

Methods: A cross-sectional study was conducted in 2018. A total of 683 students aged 8-15 years were recruited via a stratified cluster sampling Methods. Anthropometric indexes (waist circumference (WC), Body mass index (BMI), Waist-height ratio (WHtR), logarithm children LAP (LnCLAP), RCLAP per height (RCLAP-H)) were standardized using a z-score method (standardized variables: SWC, SBMI, SWHtR, SLnCLAP, SRCLAP-H). A logistic regression model was performed to evaluate the association of the above indicators with the outcome of hypertension.

Results: The overall prevalence of hypertension was 5.7% (5.5% in boys, 6.0% in girls). SWC ≥ P₇₅, SBMI ≥ P₇₅, SWHtR ≥ P₇₅, SlnCLAP ≥ P₇₅ and SRCLAP-H ≥ P₇₅ significantly increased risk of hypertension, with odds ratios (OR) of 2.21 (95% confidence interval (CI): 1.13, 4.30), 2.30 (1.18, 4.49), 2.64 (1.35, 5.14), 4.43 (2.28, 8.61), and 4.49 (2.31, 8.71), respectively.

Conclusion: RCLAP is a novel indicator associated with hypertension in Chinese children and adolescents, and it performs better than WC, BMI, WHtR and children LAP.

Keywords: Children and adolescents; Hypertension; children’s lipid accumulation product.