Recurrent SARS-CoV-2 RNA positivity and prolonged viral shedding in a patient with COVID-19: a case report

BMC Infect Dis. 2021 Oct 18;21(1):1076. doi: 10.1186/s12879-021-06776-3.

Abstract

Background: The ongoing coronavirus disease 2019 (COVID-19) global pandemic caused by the SARS-CoV-2 virus remains a major threat to public health. At present, it is recommended that patients with known or suspected COVID-19 undergo quarantine or medical observation for 14 days. However, recurrent SARS-CoV-2 RNA positivity and prolonged viral shedding have been documented in convalescent COVID-19 patients, complicating efforts to control viral spread and ensure patient recovery.

Case presentation: We report the case of a patient who experienced two recurrent episodes of SARS-CoV-2 RNA and IgM positivity and viral shedding over 60 days during hospitalization.

Conclusions: This case report demonstrates that relapses of SARS-CoV-2 RNA and IgM positivity may occur even after COVID-19 symptoms have resolved, possibly as a consequence of prolonged viral shedding rather than re-infection.

Keywords: COVID-19; Coronavirus; IgM; Recurrence; SARS-CoV-2; Viral shedding.

Publication types

  • Case Reports

MeSH terms

  • COVID-19*
  • Humans
  • RNA, Viral* / genetics
  • SARS-CoV-2
  • Virus Shedding

Substances

  • RNA, Viral