Electrospun sodium alginate/poly(ethylene oxide) core-shell nanofibers scaffolds potential for tissue engineering applications

Guiping Ma; Dawei Fang; Yang Liu; Xiaodan Zhu; Jun Nie

doi:10.1016/j.carbpol.2011.08.055

Electrospun sodium alginate/poly(ethylene oxide) core-shell nanofibers scaffolds potential for tissue engineering applications

Carbohydr Polym. 2012 Jan 4;87(1):737-743. doi: 10.1016/j.carbpol.2011.08.055. Epub 2011 Aug 25.

Authors

Guiping Ma¹, Dawei Fang², Yang Liu², Xiaodan Zhu², Jun Nie³

Affiliations

¹ State Key Laboratory of Chemical Resource Engineering, Key Laboratory of Carbon Fiber and Functional Polymers, Ministry of Education, Beijing University of Chemical Technology, Beijing 100029, PR China. Electronic address: magp@mail.buct.edu.cn.
² School of Materials Science and Engineering, Changhzou University, Changzhou, Jiangsu 213164, PR China.
³ State Key Laboratory of Chemical Resource Engineering, Key Laboratory of Carbon Fiber and Functional Polymers, Ministry of Education, Beijing University of Chemical Technology, Beijing 100029, PR China. Electronic address: niejun@mail.buct.edu.cn.

PMID: 34663029
DOI: 10.1016/j.carbpol.2011.08.055

Abstract

Core-shell structure nanofibers of sodium alginate/poly(ethylene oxide) were prepared via electrospinning their dispersions in water solution. The core-shell structure morphology of the obtained nanofibers was viewed under scanning electron microscope (SEM) and transmission electron microscope (TEM), and X-ray photoelectron spectroscopy (XPS) analysis was used to further quantify the chemical composition of the core-shell composite SA/PEO nanofibers surface in detail. Furthermore, one-step cross-linking method through being immersed in CaCl₂ solution was investigated to improve the anti-water property of the electrospun nanofibers mats in order to facilitate their practical applications as tissue engineering scaffolds, and the changes of the structural of nanofibers before and after cross-linking was characterized by Fourier transform infrared (FT-IR). Indirect cytotoxicity assessment indicated that SA/PEO nanofibers membrane was nontoxic to the fibroblasts cells, and cell culture suggested that SA/PEO nanofibers tended to promote fibroblasts cells attachment and proliferation. It was assumed that the nanofibers membrane of electrospun SA/PEO could be used for tissue engineering scaffolds.

Keywords: Core–shell; Electrospinning; Nanofibers; Sodium alginate; Tissue engineering.