Protein and peptide delivery to lungs by using advanced targeted drug delivery

Dinesh Kumar Chellappan; Parteek Prasher; Vilashini Saravanan; Vanessa See Vern Yee; Wendy Chai Wen Chi; Jia Wei Wong; Joon Kang Wong; Jing Tong Wong; Wai Wan; Jestin Chellian; Nagashekhara Molugulu; Sakthivel Lakshmana Prabu; Rania Ibrahim; Thiviya Darmarajan; Mayuren Candasamy; Pankaj Kumar Singh; Vijay Mishra; Madhur D Shastri; Flavia C Zacconi; Amlan Chakraborty; Meenu Mehta; Piyush Kumar Gupta; Harish Dureja; Monica Gulati; Sachin Kumar Singh; Gaurav Gupta; Niraj Kumar Jha; Brian Gregory George Oliver; Kamal Dua

doi:10.1016/j.cbi.2021.109706

Protein and peptide delivery to lungs by using advanced targeted drug delivery

Chem Biol Interact. 2022 Jan 5:351:109706. doi: 10.1016/j.cbi.2021.109706. Epub 2021 Oct 15.

Authors

Dinesh Kumar Chellappan¹, Parteek Prasher², Vilashini Saravanan³, Vanessa See Vern Yee³, Wendy Chai Wen Chi³, Jia Wei Wong³, Joon Kang Wong³, Jing Tong Wong³, Wai Wan³, Jestin Chellian⁴, Nagashekhara Molugulu⁵, Sakthivel Lakshmana Prabu⁶, Rania Ibrahim⁷, Thiviya Darmarajan⁷, Mayuren Candasamy⁴, Pankaj Kumar Singh⁸, Vijay Mishra⁹, Madhur D Shastri¹⁰, Flavia C Zacconi¹¹, Amlan Chakraborty¹², Meenu Mehta¹³, Piyush Kumar Gupta¹⁴, Harish Dureja¹⁵, Monica Gulati⁹, Sachin Kumar Singh⁹, Gaurav Gupta¹⁶, Niraj Kumar Jha¹⁷, Brian Gregory George Oliver¹⁸, Kamal Dua¹⁹

Affiliations

¹ Department of Life Sciences, School of Pharmacy, International Medical University, Bukit Jalil 57000, Kuala Lumpur, Malaysia. Electronic address: dinesh_kumar@imu.edu.my.
² Department of Chemistry, UGC-Sponsored Centre for Advanced Studies, Guru Nanak Dev University, Amritsar 143005, India; Department of Chemistry, University of Petroleum & Energy Studies, Dehradun 248007, India.
³ School of Pharmacy, International Medical University, Bukit Jalil 57000, Kuala Lumpur, Malaysia.
⁴ Department of Life Sciences, School of Pharmacy, International Medical University, Bukit Jalil 57000, Kuala Lumpur, Malaysia.
⁵ School of Pharmacy, Monash University Malaysia, Jalan Lagoon Selatan, Bandar Sunway, 47500 Subang Jaya, Selangor, Malaysia.
⁶ Department of Pharmaceutical Technology, University College of Engineering (BIT Campus), Anna University, Tiruchirappalli 620024, India.
⁷ School of Health Sciences, International Medical University, Bukit Jalil 57000, Kuala Lumpur, Malaysia.
⁸ Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad, Telangana 500037, India.
⁹ School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, 144411, India.
¹⁰ School of Pharmacy and Pharmacology, University of Tasmania, Hobart, Australia.
¹¹ Departamento de Química Orgánica, Facultad de Química y de Farmacia, Pontificia Universidad Católica deChile, Av. Vicuña Mackenna 4860, Macul, Santiago 7820436, Chile; Institute for Biological and Medical Engineering, Schools of Engineering, Medicine and Biological Sciences, Pontificia Universidad Católica de Chile, Santiago, Chile.
¹² Department of Pharmacology, Biomedicine Discovery Institute, Monash University, Melbourne, Victoria, Australia.
¹³ Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, NSW 2007, Australia; Faculty of Health, Australian Research Centre in Complementary and Integrative Medicine, University of Technology Sydney, Ultimo, Australia.
¹⁴ Department of Life Sciences, School of Basic Sciences and Research, Sharda University, Knowledge Park III, Greater Noida - 201310, Uttar Pradesh, India.
¹⁵ Department of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak - 124001, India.
¹⁶ School of Pharmacy, Suresh Gyan Vihar University, Jagatpura, Jaipur, India.
¹⁷ Department of Biotechnology, School of Engineering & Technology, Sharda University, Greater Noida, Uttar Pradesh, 201310, India.
¹⁸ School of Life Sciences, University of Technology Sydney, Ultimo, NSW 2007, Australia; Woolcock Institute of Medical Research, University of Sydney, Sydney, New South Wales, Australia. Electronic address: Brian.Oliver@uts.edu.au.
¹⁹ Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, NSW 2007, Australia; Faculty of Health, Australian Research Centre in Complementary and Integrative Medicine, University of Technology Sydney, Ultimo, Australia. Electronic address: Kamal.Dua@uts.edu.au.

PMID: 34662570
DOI: 10.1016/j.cbi.2021.109706

Abstract

The challenges and difficulties associated with conventional drug delivery systems have led to the emergence of novel, advanced targeted drug delivery systems. Therapeutic drug delivery of proteins and peptides to the lungs is complicated owing to the large size and polar characteristics of the latter. Nevertheless, the pulmonary route has attracted great interest today among formulation scientists, as it has evolved into one of the important targeted drug delivery platforms for the delivery of peptides, and related compounds effectively to the lungs, primarily for the management and treatment of chronic lung diseases. In this review, we have discussed and summarized the current scenario and recent developments in targeted delivery of proteins and peptide-based drugs to the lungs. Moreover, we have also highlighted the advantages of pulmonary drug delivery over conventional drug delivery approaches for peptide-based drugs, in terms of efficacy, retention time and other important pharmacokinetic parameters. The review also highlights the future perspectives and the impact of targeted drug delivery on peptide-based drugs in the coming decade.

Keywords: Chronic diseases; Drug delivery; Lung diseases; Nanotechnology; Peptides; Proteins; Respiratory; Targeted.

Publication types

Review

MeSH terms

Administration, Inhalation
Animals
Drug Carriers / administration & dosage
Drug Carriers / chemistry*
Humans
Lung / drug effects
Lung / metabolism*
Lung Diseases / drug therapy
Nanoparticles / administration & dosage
Nanoparticles / chemistry
Peptides / administration & dosage*
Peptides / therapeutic use
Proteins / administration & dosage*
Proteins / therapeutic use

Substances

Drug Carriers
Peptides
Proteins