Critically Ill Patient with Multidrug-Resistant Acinetobacter baumannii Respiratory Infection Successfully Treated with Intravenous and Nebulized Bacteriophage Therapy

Antimicrob Agents Chemother. 2022 Jan 18;66(1):e0082421. doi: 10.1128/AAC.00824-21. Epub 2021 Oct 18.

Abstract

Hospitalized patients are at risk of developing serious multidrug resistant bacterial infections. This risk is heightened in patients who are on mechanical ventilation, are immunocompromised, and/or have chronic comorbidities. We report the case of a 52-year-old critically ill patient with a multidrug resistant Acinetobacter baumannii (MDR-A) respiratory infection who was successfully treated with antibiotics and intravenous and nebulized bacteriophage therapy.

Keywords: Acinetobacter; Acinetobacter baumannii; bacteriophage; bacteriophage therapy; mechanical ventilation; multidrug resistance; multidrug-resistant bacterial infection.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acinetobacter Infections* / drug therapy
  • Acinetobacter Infections* / microbiology
  • Acinetobacter baumannii*
  • Anti-Bacterial Agents / pharmacology
  • Anti-Bacterial Agents / therapeutic use
  • Critical Illness
  • Cross Infection* / microbiology
  • Drug Resistance, Multiple, Bacterial
  • Humans
  • Middle Aged
  • Phage Therapy*
  • Respiratory Tract Infections* / drug therapy

Substances

  • Anti-Bacterial Agents