Endoplasmic Reticulum Quality Control in Immune Cells

Yalan Jiang; Zehua Tao; Hua Chen; Sheng Xia

doi:10.3389/fcell.2021.740653

Endoplasmic Reticulum Quality Control in Immune Cells

Front Cell Dev Biol. 2021 Sep 29:9:740653. doi: 10.3389/fcell.2021.740653. eCollection 2021.

Authors

Yalan Jiang¹, Zehua Tao¹, Hua Chen², Sheng Xia¹

Affiliations

¹ Department of Immunology, School of Medicine, Jiangsu University, Zhenjiang, China.
² Department of Colorectal Surgery, Affiliated Kunshan Hospital of Jiangsu University, Kunshan, China.

Abstract

The endoplasmic reticulum quality control (ERQC) system, including endoplasmic reticulum-associated degradation (ERAD), the unfolded protein response (UPR), and autophagy, presides over cellular protein secretion and maintains proteostasis in mammalian cells. As part of the immune system, a variety of proteins are synthesized and assembled correctly for the development, activation, and differentiation of immune cells, such as dendritic cells (DCs), macrophages, myeloid-derived-suppressor cells (MDSCs), B lymphocytes, T lymphocytes, and natural killer (NK) cells. In this review, we emphasize the role of the ERQC in these immune cells, and also discuss how the imbalance of ER homeostasis affects the immune response, thereby suggesting new therapeutic targets for immunotherapy.

Keywords: ERAD; ERQC; UPR; autophagy; immune cell.

Publication types

Review