Phytosynthesis of Titanium Dioxide Nanoparticles Using King of Bitter Andrographis paniculata and Its Embryonic Toxicology Evaluation and Biomedical Potential

S Rajeshkumar; J Santhoshkumar; Leta Tesfaye Jule; Krishnaraj Ramaswamy

doi:10.1155/2021/6267634

Phytosynthesis of Titanium Dioxide Nanoparticles Using King of Bitter Andrographis paniculata and Its Embryonic Toxicology Evaluation and Biomedical Potential

Bioinorg Chem Appl. 2021 Oct 7:2021:6267634. doi: 10.1155/2021/6267634. eCollection 2021.

Authors

S Rajeshkumar¹, J Santhoshkumar¹, Leta Tesfaye Jule^{2

3}, Krishnaraj Ramaswamy^{3

4}

Affiliations

¹ Nanobiomedicine Lab, Department of Pharmacology, Saveetha Dental College and Hospital, SIMATS, Chennai 600077, TN, India.
² Department of Physics, College of Natural and Computational Science, Dambi Dollo University, Dambi Dollo, Ethiopia.
³ Centre for Excellence-Indigenous Knowledge Innovative Technology Transfer and Entrepreneurship, Dambi Dollo University, Dambi Dollo, Ethiopia.
⁴ Department of Mechanical Engineering, College of Engineering and Technology, Dambi Dollo University, Dambi Dollo, Ethiopia.

Abstract

Phytosynthesis particles are the efficient activity of biomedical and environmental. In this present study, the green synthesis of titanium dioxide (TiO₂) nanoparticles using the king of bitter herbal plant Andrographis paniculata was synthesized and characterized using XRD, SEM, HRTEM, AFM, and antimicrobial, antioxidant, and antidiabetic activities. The size of the particles HRTEM shows 50 nm, and SEM shows the spherical shape, which reveals the synthesis of TiO₂ nanoparticles. XRD spectrum shows crystallinity of nanoparticles, and an average size is calculated about 22.97 nm. The phytosynthesis TiO₂ shows the antioxidant and antidiabetic activities. Similarly, toxicity studies have demonstrated the hatching and viability LD 50 value of TiO₂ 250 μg/L. The current study's findings suggested that phytosynthesis TiO₂ using extract of Andrographis paniculata exposure to potential hazard factors to biomedical and environmental uses.