Subtypes of Histopathologically Classical Aldosterone-Producing Adenomas Yield Various Transcriptomic Signaling and Outcomes

Hypertension. 2021 Dec;78(6):1791-1800. doi: 10.1161/HYPERTENSIONAHA.121.18006. Epub 2021 Oct 18.

Vin-Cent Wu¹, Kang-Yung Peng², Yu-Ping Kuo, Hsuan Liu^{2

3

4

5}, Bertrand Chin-Ming Tan^{3

6

7

8}, Yen-Hung Lin⁹, Tai-Shuan Lai¹, Yung-Ming Chen¹, Jeff S Chueh¹⁰; TAIPAI

¹ Division of Nephrology (V.-C.W., T.-S.L., Y.-M.C.), National Taiwan University Hospital, Taipei.
² Molecular Medicine Research Center, Chang Gung University, Taoyuan, Taiwan (H.L., K.-Y.P.).
³ Graduate Institute of Biomedical Sciences (H.L., B.C.-M.T.), Chang Gung University, Taoyuan, Taiwan.
⁴ Department of Cell and Molecular Biology (H.L.), Chang Gung University, Taoyuan, Taiwan.
⁵ Division of Colon and Rectal Surgery, Department of Neurosurgery (H.L.), Taoyuan, Taiwan. TAIPAI group, Taiwan Primary Aldosteronism Investigation, Taipei, Taiwan.
⁶ Department of Biomedical Sciences, Research Center for Emerging Viral Infections (B.C.-M.T.), Chang Gung University, Taoyuan, Taiwan.
⁷ College of Medicine (B.C.-M.T.), Chang Gung University, Taoyuan, Taiwan.
⁸ Lin-Kou Medical Center, Chang Gung Memorial Hospital (B.C.-M.T.), Taoyuan, Taiwan. TAIPAI group, Taiwan Primary Aldosteronism Investigation, Taipei, Taiwan.
⁹ Division of Cardiology, Department of Internal Medicine (Y.-H.L.), National Taiwan University Hospital, Taipei.
¹⁰ Department of Urology, College of Medicine (J.S.C.), National Taiwan University Hospital, Taipei.

Abstract

[Figure: see text].

Keywords: HTR2B; adrenal gland; aldosterone; classical adenoma; hypertension; multiple aldosterone-producing micronodules.