Enhanced stability of stilbene-glycoside-loaded nanoparticles coated with carboxymethyl chitosan and chitosan hydrochloride

Shiqi Liu; Qianyu Yang; Jing Zhang; Mengnan Yang; Yanhui Wang; Ting Sun; Chao Ma; A M Abd El-Aty

doi:10.1016/j.foodchem.2021.131343

Enhanced stability of stilbene-glycoside-loaded nanoparticles coated with carboxymethyl chitosan and chitosan hydrochloride

Food Chem. 2022 Mar 15:372:131343. doi: 10.1016/j.foodchem.2021.131343. Epub 2021 Oct 6.

Authors

Shiqi Liu¹, Qianyu Yang², Jing Zhang², Mengnan Yang², Yanhui Wang², Ting Sun², Chao Ma³, A M Abd El-Aty⁴

Affiliations

¹ College of Biological Science and Technology, Beijing Key Laboratory of Forest Food Processing and Safety, Beijing Forestry University, Beijing 100083, China. Electronic address: liushiqi97@bjfu.edu.cn.
² College of Biological Science and Technology, Beijing Key Laboratory of Forest Food Processing and Safety, Beijing Forestry University, Beijing 100083, China.
³ College of Biological Science and Technology, Beijing Key Laboratory of Forest Food Processing and Safety, Beijing Forestry University, Beijing 100083, China. Electronic address: machao@bjfu.edu.cn.
⁴ State Key Laboratory of Biobased Material and Green Papermaking, College of Food Science and Engineering, Qilu University of Technology, Shandong Academy of Science, Jinan 250353, China; Department of Pharmacology, Faculty of Veterinary Medicine, Cairo University, Giza 12211, Egypt; Department of Medical Pharmacology, Faculty of Medicine, Atatürk University, Erzurum, Turkey. Electronic address: abdelaty44@hotmail.com.

PMID: 34656910
DOI: 10.1016/j.foodchem.2021.131343

Abstract

Stilbene-glycoside (THSG) is a promising dietary supplement with remarkable biological properties, however, its poor stability and low oral bioavailability hinder its application as an ingredient in functional foods. Herein, stilbene-glycoside-loaded nanoparticles (THSG-NPs) coated with carboxymethyl chitosan (CMC) and chitosan hydrochloride (CHC) using a complex coacervation method were successfully prepared for enhancing the stability of THSG. The optimized preparation parameters were 2.5 mg/mL CMC, 1.0 mg/mL CHC, 1.5 mg/mL THSG and preparation temperature of 25 °C, under which the experimentally designed particles averaged 381.9 nm with encapsulation efficiency (EE) of 68.6%. Solid-state characterization was assessed by Fourier transform infrared spectroscope and Differential scanning calorimetry. THSG-NPs showed significant protective effects against heat and solar radiation and exhibited remarkable pH-dependent and controlled release. This work demonstrated that enhanced stability and delayed release of THSG could be achieved using THSG-NPs, which could contribute to its potential application in the functional foods industry.

Keywords: Carboxymethyl chitosan; Chitosan hydrochloride; Complex coacervation; Stability; Stilbene-glycoside.

MeSH terms

Chitosan*
Drug Carriers
Glycosides
Nanoparticles*
Particle Size
Stilbenes*

Substances

Drug Carriers
Glycosides
Stilbenes
Chitosan