Phonocardiogram signal analysis for classification of Coronary Artery Diseases using MFCC and 1D adaptive local ternary patterns

Abstract

Coronary Artery Diseases (CADs) are a dominant cause of worldwide fatalities. The development of accurate and timely diagnosis routines is imperative to reduce these risks and mortalities. Coronary angiography, an invasive and expensive technique, is currently used as a diagnostic tool for the detection of CAD but it has some procedural hazards, i.e., it requires arterial puncture, and the subject gets exposed to iodinated radiation. Phonocardiography (PCG), a non-invasive and inexpensive technique, is a modality employing heart sounds to diagnose heart diseases but it requires only trained medical personnel to apprehend cardiac murmurs in clinical environments. Furthermore, there is a strong compulsion to characterize CAD into its types, such as Single vessel coronary artery disease (SVCAD), Double vessel coronary artery disease (DVCAD), and Triple vessel coronary artery disease (TVCAD) to assist the cardiologist in decision making about the treatment procedure followed. This paper presents a computer-aided diagnosis system for the categorization of CAD and its types based on Phonocardiogram (PCG) signal analysis. The raw PCG signals were denoised via empirical mode decomposition (EMD) to remove redundant information and noise. Next, we extract MFCC and proposed 1D-Adaptive Local Ternary Patterns (1D-ALTP) and fused them serially to get a strong feature representation of multiple PCG signal classes. Features were further reduced through Multidimensional Scaling (MDS) and subjected to several classification methods such as support vector machines (SVM), Decision Tree (DT), and K-nearest neighbors (KNN) in a comparative fashion. The best classification performances of 98.3% and 97.2% mean accuracies were obtained through SVM with the cubic kernel for binary and multiclass experiments, respectively. The performance of the proposed system is comprehensively tested through 10-fold cross-validation and hold-out train-test techniques to avoid model overfitting. Comparative analysis with existing approaches advocates the superiority of the proposed approach.

Keywords: 1D-adaptive local ternary patterns; Classification; Computer-aided diagnosis; Coronary artery disease; Feature extraction; Phonocardiogram (PCG).