Altered brain network in first-episode, drug-naive patients with major depressive disorder

Abstract

Background: Resting-state functional magnetic resonance imaging has been widely used for the assessment of brain functional network, yet with inconsistent results. The present study aimed to investigate intranetwork and internetwork connectivity differences between patients with major depressive disorder (MDD) and healthy controls at the integrity, network and edge levels of 8 well-defined resting state networks.

Methods: Thirty patients with MDD and sixty-three healthy control subjects were recruited in this study.

Results: Compared with healthy controls, patients with MDD showed increased node degree in the right amygdala and putamen, increased connectivity strength in the deep gray matter network (DGN) and increased functional connectivity in intranetwork and internetwork. Meanwhile, MDD showed decreased connectivity strength in visual network-DGN pair.

Limitations: The sample size was small, and all patients in this study were of Asian ethnicity, especially Han individuals.

Conclusions: These findings demonstrate that MDD cases and healthy controls may have divergent intranetwork and internetwork connectivity at an early stage without confounding influence of medication. These differences may underlie cognitive and behavioral alterations in patients with MDD. And these differences may help with the discrimination of patients and healthy people at an early stage of MDD. More studies in the future are warranted to assist in the diagnosis of this burdensome disease.

Keywords: Functional network; Internetwork; Intranetwork; Major depressive disorder; Resting-state functional magnetic resonance imaging.