Analysis of positional isomers of 2-3-4-alkoxyphenylcarbamic acid derivatives by a combination of TLC and IMS

Abstract

In this study, we have demonstrated a separation of positional isomers of some derivatives of alkoxyphenylcarbamic acid. These compounds belong to drugs with local anesthetics activity. The low volatility compounds were analysed by a Thin Layer Chromatography (TLC) and Ion Mobility Spectrometry (IMS) using diode laser desorption for sample introduction to IMS. This combined approach allowed the identification of compounds. Also, we have carried out IMS studies of all compounds and determined their ion mobilities The ion mobilities were increasing with the geometry change from position ortho to para of alkoxy chain, which is in agreement with their different collision cross section (CCS).

Keywords: Alkoxyphenylcarbamic acid; Ion Mobility Spectrometry; Positional isomers; Thin Layer Chromatography.