The role of GPR56/ADGRG1 in health and disease

Abhishek Kumar Singh; Hsi-Hsien Lin

doi:10.1016/j.bj.2021.04.012

The role of GPR56/ADGRG1 in health and disease

Biomed J. 2021 Oct;44(5):534-547. doi: 10.1016/j.bj.2021.04.012. Epub 2021 May 4.

Authors

Abhishek Kumar Singh¹, Hsi-Hsien Lin²

Affiliations

¹ Department of Biological Sciences, Indian Institute of Science Education and Research, Mohali, India.
² Department of Microbiology and Immunology, College of Medicine, Chang Gung University, Taoyuan, Taiwan; Division of Rheumatology, Allergy and Immunology, Chang Gung Memorial Hospital at Keelung, Keelung, Taiwan; Department of Anatomic Pathology, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan. Electronic address: hhlin@mail.cgu.edu.tw.

Abstract

GPR56/ADGRG1 is a versatile adhesion G protein-coupled receptor important in the physiological functions of the central and peripheral nervous systems, reproductive system, muscle hypertrophy, immune regulation, and hematopoietic stem cell generation. By contrast, aberrant expression or deregulated functions of GPR56 have been implicated in diverse pathological processes, including bilateral frontoparietal polymicrogyria, depression, and tumorigenesis. In this review article, we summarize and discuss the current understandings of the role of GPR56 in health and disease.

Keywords: Adhesion GPCR; G protein; Ligand; Signaling.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Cell Transformation, Neoplastic
Depression
Humans
Malformations of Cortical Development
Receptors, G-Protein-Coupled* / physiology

Substances

ADGRG1 protein, human
Receptors, G-Protein-Coupled