In this work, we address a multicoupled dynamics on complex networks with tunable structural segregation. Specifically, we work on a networked epidemic spreading under a vaccination campaign with agents in favor and against the vaccine. Our results show that such coupled dynamics exhibits a myriad of phenomena such as nonequilibrium transitions accompanied by bistability. Besides we observe the emergence of an intermediate optimal segregation level where the community structure enhances negative opinions over vaccination but counterintuitively hinders-rather than favoring-the global disease spreading. Thus our results hint vaccination campaigns should avoid policies that end up segregating excessively antivaccine groups so that they effectively work as echo chambers in which individuals look to confirmation without jeopardizing the safety of the whole population.