Cavitary retinoblastoma: A review of literature

Vishal Raval; Swathi Kaliki

doi:10.1016/j.survophthal.2021.10.002

Cavitary retinoblastoma: A review of literature

Surv Ophthalmol. 2022 May-Jun;67(3):723-728. doi: 10.1016/j.survophthal.2021.10.002. Epub 2021 Oct 11.

Authors

Vishal Raval¹, Swathi Kaliki²

Affiliations

¹ The Operation Eyesight Universal Institute for Eye Cancer, L V Prasad Eye Institute, Hyderabad, India. Electronic address: drvishalraval@gmail.com.
² The Operation Eyesight Universal Institute for Eye Cancer, L V Prasad Eye Institute, Hyderabad, India.

PMID: 34648817
DOI: 10.1016/j.survophthal.2021.10.002

Abstract

Cavitary retinoblastoma is a rare tumor variant manifesting in the form of ophthalmoscopically visible translucent cavities within the tumor. The pathogenesis of the cavitary variant is unknown. Histopathologically, the cavitary spaces represent photoreceptor differentiation in the areas adjacent to the cavitations, which might explain variable response to chemotherapy with lower risk of reactivation and good prognosis. There is, however, little understanding about its origin, frequency, pathogenesis, and clinical significance. In this systematic review of the literature, we analyze epidemiology, clinical presentation, genetic implications, imaging, and treatment outcomes of various regimens (intravenous, intra-arterial, and focal) in terms of local control, recurrences, and globe salvage rates.

Keywords: Cancer; Cavitary; Cavity; Eye; Imaging; Retinoblastoma; Treatment.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Humans
Infant
Retinal Neoplasms* / diagnosis
Retinal Neoplasms* / epidemiology
Retinal Neoplasms* / therapy
Retinoblastoma* / diagnosis
Retinoblastoma* / epidemiology
Retinoblastoma* / therapy
Retrospective Studies
Treatment Outcome