Inhibition of the NLRP3 inflammasome with MCC950 prevents chronic social isolation-induced depression-like behavior in male mice

Neurosci Lett. 2021 Nov 20:765:136290. doi: 10.1016/j.neulet.2021.136290. Epub 2021 Oct 10.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Behavior, Animal / drug effects
  • Depression / etiology*
  • Furans / pharmacology*
  • Hippocampus / drug effects
  • Indenes / pharmacology*
  • Inflammasomes / antagonists & inhibitors*
  • Male
  • Mice
  • Mice, Inbred C57BL
  • NLR Family, Pyrin Domain-Containing 3 Protein / antagonists & inhibitors
  • Neuronal Plasticity / drug effects*
  • Social Isolation / psychology*
  • Sulfonamides / pharmacology*

Substances

  • Furans
  • Indenes
  • Inflammasomes
  • NLR Family, Pyrin Domain-Containing 3 Protein
  • Nlrp3 protein, mouse
  • Sulfonamides
  • N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide