Sintered and 3D-Printed Bulks of MgB2-Based Materials with Antimicrobial Properties

Molecules. 2021 Oct 6;26(19):6045. doi: 10.3390/molecules26196045.

Abstract

Pristine high-density bulk disks of MgB2 with added hexagonal BN (10 wt.%) were prepared using spark plasma sintering. The BN-added samples are machinable by chipping them into desired geometries. Complex shapes of different sizes can also be obtained by the 3D printing of polylactic acid filaments embedded with MgB2 powder particles (10 wt.%). Our present work aims to assess antimicrobial activity quantified as viable cells (CFU/mL) vs. time of sintered and 3D-printed materials. In vitro antimicrobial tests were performed against the bacterial strains Escherichia coli ATCC 25922, Pseudomonas aeruginosa ATCC 27853, Staphylococcus aureus ATCC 25923, Enterococcus faecium DSM 13590, and Enterococcus faecalis ATCC 29212; and the yeast strain Candida parapsilosis ATCC 22019. The antimicrobial effects were found to depend on the tested samples and microbes, with E. faecium being the most resistant and E. coli the most susceptible.

Keywords: 3D printing; MgB2; antimicrobial activity; machinable material; spark plasma sintering.

MeSH terms

  • Anti-Infective Agents / pharmacology*
  • Bacteria / drug effects*
  • Boron Compounds / pharmacology*
  • Candida parapsilosis / drug effects
  • Enterococcus faecalis / drug effects
  • Enterococcus faecium / drug effects
  • Escherichia coli / drug effects
  • Fungi / drug effects*
  • Magnesium Compounds / pharmacology*
  • Microbial Sensitivity Tests
  • Polyesters / pharmacology
  • Printing, Three-Dimensional
  • Pseudomonas aeruginosa / drug effects
  • Staphylococcus aureus / drug effects

Substances

  • Anti-Infective Agents
  • Boron Compounds
  • Magnesium Compounds
  • Polyesters
  • magnesium boride
  • poly(lactide)