Elevated levels of serum CD5 antigen-like protein distinguish secondary progressive multiple sclerosis from other disease subtypes

Emily Kamma; Pierre Becquart; Anthony Traboulsee; Alice Schabas; Irene M Vavasour; Cornelia Laule; Carles Vilariño-Güell; Jacqueline A Quandt

doi:10.1016/j.msard.2021.103269

Elevated levels of serum CD5 antigen-like protein distinguish secondary progressive multiple sclerosis from other disease subtypes

Mult Scler Relat Disord. 2021 Nov:56:103269. doi: 10.1016/j.msard.2021.103269. Epub 2021 Sep 20.

Authors

Emily Kamma¹, Pierre Becquart², Anthony Traboulsee³, Alice Schabas⁴, Irene M Vavasour⁵, Cornelia Laule⁶, Carles Vilariño-Güell⁷, Jacqueline A Quandt⁸

Affiliations

¹ Department of Pathology & Laboratory Medicine, Faculty of Medicine, University of British Columbia, Vancouver, Canada. Electronic address: emily.kamma@ubc.ca.
² Department of Pathology & Laboratory Medicine, Faculty of Medicine, University of British Columbia, Vancouver, Canada. Electronic address: pierre.becquart@ubc.ca.
³ Division of Neurology, Department of Medicine, Faculty of Medicine, University of British Columbia, Vancouver, Canada. Electronic address: t.traboulsee@ubc.ca.
⁴ Division of Neurology, Department of Medicine, Faculty of Medicine, University of British Columbia, Vancouver, Canada. Electronic address: alice.schabas@vch.ca.
⁵ Department of Radiology, Faculty of Medicine, University of British Columbia, Vancouver, Canada; International Collaboration on Repair Discoveries (ICORD), Faculty of Medicine, University of British Columbia, Vancouver, Canada. Electronic address: lees@phas.ubc.ca.
⁶ Department of Pathology & Laboratory Medicine, Faculty of Medicine, University of British Columbia, Vancouver, Canada; Department of Radiology, Faculty of Medicine, University of British Columbia, Vancouver, Canada; International Collaboration on Repair Discoveries (ICORD), Faculty of Medicine, University of British Columbia, Vancouver, Canada; Department of Physics & Astronomy, Faculty of Science, University of British Columbia, Vancouver, Canada. Electronic address: claule@physics.ubc.ca.
⁷ Department of Medical Genetics, Faculty of Medicine, University of British Columbia, Vancouver, Canada. Electronic address: carles@can.ubc.ca.
⁸ Department of Pathology & Laboratory Medicine, Faculty of Medicine, University of British Columbia, Vancouver, Canada; International Collaboration on Repair Discoveries (ICORD), Faculty of Medicine, University of British Columbia, Vancouver, Canada. Electronic address: jquandt@pathology.ubc.ca.

PMID: 34638097
DOI: 10.1016/j.msard.2021.103269

Abstract

CD5 antigen-like (CD5L) protein is a macrophage-secreted protein with roles in immunomodulation and lipid homeostasis. We compared serum CD5L levels in healthy controls to individuals diagnosed with clinically isolated syndrome, relapsing remitting (RR), secondary progressive (SP), and primary progressive (PP) multiple sclerosis (MS). CD5L was increased in SPMS relative to controls, RRMS, and PPMS. SPMS CD5L was associated with longer disease duration independent of age, sex, or disease severity. The positive relationship between CD5L and disease duration in SPMS suggests a chronic peripheral inflammatory profile compared to other subtypes, particularly PPMS, warranting investigation of functional roles for CD5L in MS.

Keywords: CD5L; Disease duration; Inflammation; Multiple sclerosis.

Publication types

Letter

MeSH terms

CD5 Antigens
Humans
Inflammation
Multiple Sclerosis* / diagnosis
Multiple Sclerosis, Chronic Progressive* / diagnosis
Multiple Sclerosis, Relapsing-Remitting*

Substances

CD5 Antigens