Generation of permanent neonatal diabetes mellitus dogs with glucokinase point mutations through base editing

Xiaomin Wang; Yanhui Liang; Jianping Zhao; Yuan Li; Shixue Gou; Min Zheng; Juanjuan Zhou; Quanjun Zhang; Jidong Mi; Liangxue Lai

doi:10.1038/s41421-021-00304-y

Generation of permanent neonatal diabetes mellitus dogs with glucokinase point mutations through base editing

Cell Discov. 2021 Oct 12;7(1):92. doi: 10.1038/s41421-021-00304-y.

Authors

Xiaomin Wang^#^{1

2

3

4

5}, Yanhui Liang^#^{1

2

3

4}, Jianping Zhao^#⁶, Yuan Li⁶, Shixue Gou^{1

2

3

4}, Min Zheng⁶, Juanjuan Zhou^{1

3

4}, Quanjun Zhang^{1

3

4}, Jidong Mi⁷, Liangxue Lai^{8

9

10}

Affiliations

¹ CAS Key Laboratory of Regenerative Biology, Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, 510530, China.
² University of Chinese Academy of Sciences, Beijing, 100049, China.
³ Bioland Laboratory (Guangzhou Regenerative Medicine and Health Guangdong Laboratory), Guangzhou, 510005, China.
⁴ Research Unit of Generation of Large Animal Disease Models, Chinese Academy of Medical Sciences (2019RU015), Guangzhou, 510530, China.
⁵ School of Life Sciences, Westlake University, Shilongshan Road No. 18, Cloud Town, Xihu District, Hangzhou, Zhejiang, 310024, China.
⁶ Beijing SINOGENE Biotechnology Co., Ltd, Beijing, 102200, China.
⁷ Beijing SINOGENE Biotechnology Co., Ltd, Beijing, 102200, China. jidong-m@sinogene.com.cn.
⁸ CAS Key Laboratory of Regenerative Biology, Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, 510530, China. lai_liangxue@gibh.ac.cn.
⁹ Bioland Laboratory (Guangzhou Regenerative Medicine and Health Guangdong Laboratory), Guangzhou, 510005, China. lai_liangxue@gibh.ac.cn.
¹⁰ Research Unit of Generation of Large Animal Disease Models, Chinese Academy of Medical Sciences (2019RU015), Guangzhou, 510530, China. lai_liangxue@gibh.ac.cn.

^# Contributed equally.

No abstract available

Publication types

Letter