Gastroprotective effects of extract of Jasminum grandiflorum L. flower in HCl/EtOH-induced gastric mucosal ulceration mice

Yizi Zhang; Lingli Sun; Xingfei Lai; Xingjia Peng; Shuai Wen; Zhenbiao Zhang; Yinzheng Xie; Qiuhua Li; Ruohong Chen; Xi Zheng; Kun Zhang; Shili Sun; Dongli Li

doi:10.1016/j.biopha.2021.112268

Gastroprotective effects of extract of Jasminum grandiflorum L. flower in HCl/EtOH-induced gastric mucosal ulceration mice

Biomed Pharmacother. 2021 Dec:144:112268. doi: 10.1016/j.biopha.2021.112268. Epub 2021 Oct 9.

Authors

Yizi Zhang¹, Lingli Sun², Xingfei Lai², Xingjia Peng¹, Shuai Wen², Zhenbiao Zhang², Yinzheng Xie¹, Qiuhua Li², Ruohong Chen², Xi Zheng¹, Kun Zhang¹, Shili Sun³, Dongli Li⁴

Affiliations

¹ School of Biotechnology and Health Sciences, Wuyi University, Jiangmen 529020, China.
² Tea Research Institute, Guangdong Academy of Agricultural Sciences / Guangdong Key Laboratory of Tea Resources Innovation & Utilization, Guangzhou 510640, China.
³ Tea Research Institute, Guangdong Academy of Agricultural Sciences / Guangdong Key Laboratory of Tea Resources Innovation & Utilization, Guangzhou 510640, China. Electronic address: sunshili@zju.edu.cn.
⁴ School of Biotechnology and Health Sciences, Wuyi University, Jiangmen 529020, China; International Healthcare Innovation Institute (Jiangmen), Jiangmen 529040, China. Electronic address: wyuchemldl@126.com.

PMID: 34634558
DOI: 10.1016/j.biopha.2021.112268

Abstract

Jasminum grandiflorum L. is a medicinal plant used to treat hepatitis and gastritis, but the mechanisms underlying its protective effects against gastrointestinal mucosal damage remain to be elucidated. In this study, we analyzed the effects of four different extracts and two compounds from the flower of J. grandiflorum in a mouse model of HCl/EtOH-induced gastric ulcer. The flower extracts alleviated gastric mucosal ulceration by increasing PGE2 production and the activity of antioxidant enzymes, along with the suppression of reactive oxygen species (ROS) generation, lipid peroxidation, apoptosis-related proteins, pro-inflammatory cytokines and nitric oxide (NO) production.

Keywords: Apoptosis; Gastrointestinal mucosal damage; Inflammation; Oxidative stress.

MeSH terms

Animals
Anti-Inflammatory Agents / pharmacology
Anti-Ulcer Agents / isolation & purification
Anti-Ulcer Agents / pharmacology*
Antioxidants / pharmacology
Apoptosis Regulatory Proteins / metabolism
Dinoprostone / metabolism
Disease Models, Animal
Ethanol
Flowers
Gastric Mucosa / drug effects*
Gastric Mucosa / metabolism
Gastric Mucosa / pathology
Hydrochloric Acid
Inflammation Mediators / metabolism
Jasminum* / chemistry
Lipid Peroxidation / drug effects
Macrophages / drug effects
Macrophages / metabolism
Male
Mice
Mice, Inbred ICR
NF-kappa B / metabolism
Nitric Oxide / metabolism
Oxidative Stress / drug effects
Plant Extracts / isolation & purification
Plant Extracts / pharmacology*
RAW 264.7 Cells
Stomach Ulcer / metabolism
Stomach Ulcer / pathology
Stomach Ulcer / prevention & control*

Substances

Anti-Inflammatory Agents
Anti-Ulcer Agents
Antioxidants
Apoptosis Regulatory Proteins
Inflammation Mediators
NF-kappa B
Plant Extracts
Nitric Oxide
Ethanol
Dinoprostone
Hydrochloric Acid