Mutations in the HIV-1 3'-Polypurine Tract Can Confer Dolutegravir Resistance

Antimicrob Agents Chemother. 2022 Jan 18;66(1):e0102721. doi: 10.1128/AAC.01027-21. Epub 2021 Oct 11.
No abstract available

Keywords: antiretroviral resistance; dolutegravir; human immunodeficiency virus.

Publication types

  • Letter
  • Research Support, N.I.H., Extramural

MeSH terms

  • Drug Resistance, Viral / genetics
  • HIV Infections* / drug therapy
  • HIV Integrase Inhibitors* / pharmacology
  • HIV Integrase Inhibitors* / therapeutic use
  • HIV-1* / genetics
  • Heterocyclic Compounds, 3-Ring / pharmacology
  • Heterocyclic Compounds, 3-Ring / therapeutic use
  • Humans
  • Mutation
  • Oxazines / pharmacology
  • Oxazines / therapeutic use
  • Piperazines
  • Pyridones / pharmacology
  • Pyridones / therapeutic use

Substances

  • HIV Integrase Inhibitors
  • Heterocyclic Compounds, 3-Ring
  • Oxazines
  • Piperazines
  • Pyridones
  • dolutegravir