Study on Transorgan Regulation of Intervertebral Disc and Extra-Skeletal Organs Through Exosomes Derived From Bone Marrow Mesenchymal Stem Cells

Zhikun Wang; Yangming Wu; Zhonghan Zhao; Chengyi Liu; Lingli Zhang

doi:10.3389/fcell.2021.741183

Study on Transorgan Regulation of Intervertebral Disc and Extra-Skeletal Organs Through Exosomes Derived From Bone Marrow Mesenchymal Stem Cells

Front Cell Dev Biol. 2021 Sep 23:9:741183. doi: 10.3389/fcell.2021.741183. eCollection 2021.

Authors

Zhikun Wang¹, Yangming Wu², Zhonghan Zhao¹, Chengyi Liu², Lingli Zhang²

Affiliations

¹ School of Kinesiology, Shanghai University of Sport, Shanghai, China.
² School of Physical Education and Sports Science, South China Normal University, Guangzhou, China.

Abstract

Exosomes are membranous lipid vesicles fused with intracellular multicellular bodies and then released into the extracellular environment. They contain various bioactive substances, including proteins, mRNA, miRNAs, lncRNAs, circRNAs, lipids, transcription factors, and cytokine receptors. Under certain conditions, bone marrow mesenchymal stem cells (BMSCs) can differentiate into osteoblasts, chondrocytes, adipocytes, and biological functions. This study provides a theoretical basis for the application of exosomes derived from bone marrow mesenchymal stem cells (BMSC-Exos) in osteology, exploring different sources of exosomes to improve bone microenvironment and resist bone metastasis. We also provided new ideas for the prevention and rehabilitation of human diseases by exosomes.

Keywords: bone marrow mesenchymal stem cells; endocrine regulation; exosomes; intervertebral disc; transorgan regulation.

Publication types

Review