New Polyprenylated Acylphloroglucinol Derivatives and Xanthones From Hypericum wilsonii

Ji Hao; Tongxi Zhou; Yuanren Ma; Jingtong Deng; Haitao Cheng; Qiang Wang; Qinxiong Lin; Xinzhou Yang; Hoyoung Choi

doi:10.3389/fchem.2021.717904

New Polyprenylated Acylphloroglucinol Derivatives and Xanthones From Hypericum wilsonii

Front Chem. 2021 Sep 24:9:717904. doi: 10.3389/fchem.2021.717904. eCollection 2021.

Authors

Ji Hao¹, Tongxi Zhou¹, Yuanren Ma¹, Jingtong Deng¹, Haitao Cheng¹, Qiang Wang¹, Qinxiong Lin¹, Xinzhou Yang¹, Hoyoung Choi²

Affiliations

¹ School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan, China.
² College of Korean Medicine, Kyung Hee University, Seoul, South Korea.

Abstract

Four new polyprenylated acylphloroglucinol derivatives, hyperwilone A-D (1-4), and two new xanthones, wilsonxanthone A (5) and wilsonxanthone B (6), together with eight known compounds were isolated from the aerial parts of Hypericum wilsonii. Their structures were expounded by comprehensive analysis of the 1D and 2D NMR spectra and HRESIMS. The relative configurations and absolute configurations of 1-6 were determined by NMR calculations and comparing their experimental and computed ECD data. All compounds were evaluated for GLUT4 translocation effects in L6 myotubes. Compound 5 showed the strongest GLUT4 translocation effects with 2.57 folds at a concentration of 30 μg/ml.

Keywords: GLUT4; Hypericum wilsonii; polyprenylated acylphloroglucinol derivatives; type 2 diabetes; xanthones.