ABO incompatibility in renal transplantation

Mahmoud Mohamed; Tara Sweeney; Duaa Alkhader; Mahmoud Nassar; Ahmed Alqassieh; Sofia Lakhdar; Nso Nso; Tibor Fülöp; Ahmed Daoud; Karim M Soliman

doi:10.5500/wjt.v11.i9.388

ABO incompatibility in renal transplantation

World J Transplant. 2021 Sep 18;11(9):388-399. doi: 10.5500/wjt.v11.i9.388.

Authors

Affiliations

¹ Department of Medicine, North Mississippi Medical Center, Tupelo, MS 38804, United States.
² Department of Medicine, Medical University of South Carolina, Charleston, SC 29425, United States.
³ Department of Surgery, Medical University of South Carolina, Charleston, SC 29425, United States.
⁴ Department of Medicine, Icahn School of Medicine at Mount Sinai, NYC Health and Hospitals, Queens, New York, NY 11432, United States.
⁵ Department of Medicine, Kasr Alainy Medical School, Cairo University, Cairo 11562, Egypt.
⁶ Department of Medicine, Medical University of South Carolina, Charleston, SC 29425, United States. drkarimsoliman@gmail.com.

Abstract

ABO blood group incompatibility (ABO-I) was historically considered an absolute contraindication to kidney transplantation due to the significant risk of acute antibody-mediated rejection and early graft loss. Nevertheless, the urge to minimize the gap between the candidates' number on the waitlist for kidney transplants and the available kidney donors encourage investigation into finding ways to use organs from ABO-I kidney donors, especially in the era of using more potent immunosuppression therapies. This review aims to discuss a general overview of ABO-I kidney transplantation and the different protocols adopted by some transplant centers to meaningfully overcome this barrier.

Keywords: ABO incompatibility; Kidney; Renal transplantation; Transplants.

Publication types

Review