Targeting the CD27-CD70 Pathway to Improve Outcomes in Both Checkpoint Immunotherapy and Allogeneic Hematopoietic Cell Transplantation

Front Immunol. 2021 Sep 22:12:715909. doi: 10.3389/fimmu.2021.715909. eCollection 2021.

Abstract

Immune checkpoint inhibitor therapies and allogeneic hematopoietic cell transplant (alloHCT) represent two distinct modalities that offer a chance for long-term cure in a diverse array of malignancies and have experienced many breakthroughs in recent years. Herein, we review the CD27-CD70 co-stimulatory pathway and its therapeutic potential in 1) combination with checkpoint inhibitor and other immune therapies and 2) its potential ability to serve as a novel approach in graft-versus-host disease (GVHD) prevention. We further review recent advances in the understanding of GVHD as a complex immune phenomenon between donor and host immune systems, particularly in the early stages with mixed chimerism, and potential novel therapeutic approaches to prevent the development of GVHD.

Keywords: CD27; CD70; allogeneic hematopoietic cell transplant (alloHCT); graft-versus-host disease (GVHD); immunotherapy.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • CD27 Ligand / metabolism*
  • Clinical Trials as Topic
  • Combined Modality Therapy
  • Graft vs Host Disease / etiology
  • Hematologic Neoplasms / etiology
  • Hematologic Neoplasms / therapy
  • Hematopoietic Stem Cell Transplantation* / adverse effects
  • Hematopoietic Stem Cell Transplantation* / methods
  • Humans
  • Immune Checkpoint Inhibitors / pharmacology*
  • Immune Checkpoint Inhibitors / therapeutic use
  • Immunotherapy
  • Molecular Targeted Therapy
  • Signal Transduction / drug effects*
  • Transplantation, Homologous
  • Treatment Outcome
  • Tumor Necrosis Factor Receptor Superfamily, Member 7 / metabolism*

Substances

  • CD27 Ligand
  • CD70 protein, human
  • Immune Checkpoint Inhibitors
  • Tumor Necrosis Factor Receptor Superfamily, Member 7