Inflammation and Oxidative Stress: Potential Targets for Improving Prognosis After Subarachnoid Hemorrhage

Fan Wu; Zongchi Liu; Ganglei Li; Lihui Zhou; Kaiyuan Huang; Zhanxiong Wu; Renya Zhan; Jian Shen

doi:10.3389/fncel.2021.739506

Inflammation and Oxidative Stress: Potential Targets for Improving Prognosis After Subarachnoid Hemorrhage

Front Cell Neurosci. 2021 Sep 24:15:739506. doi: 10.3389/fncel.2021.739506. eCollection 2021.

Authors

Fan Wu^{1

2}, Zongchi Liu^{1

2}, Ganglei Li^{1

2}, Lihui Zhou^{1

2}, Kaiyuan Huang^{1

2}, Zhanxiong Wu³, Renya Zhan^{1

2}, Jian Shen^{1

2}

Affiliations

¹ First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
² Department of Neurosurgery, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
³ College of Electronics and Information, Hangzhou Dianzi University, Hangzhou, China.

Abstract

Subarachnoid hemorrhage (SAH) has a high mortality rate and causes long-term disability in many patients, often associated with cognitive impairment. However, the pathogenesis of delayed brain dysfunction after SAH is not fully understood. A growing body of evidence suggests that neuroinflammation and oxidative stress play a negative role in neurofunctional deficits. Red blood cells and hemoglobin, immune cells, proinflammatory cytokines, and peroxidases are directly or indirectly involved in the regulation of neuroinflammation and oxidative stress in the central nervous system after SAH. This review explores the role of various cellular and acellular components in secondary inflammation and oxidative stress after SAH, and aims to provide new ideas for clinical treatment to improve the prognosis of SAH.

Keywords: anti-inflammatory; antioxidant; delayed ischemic neurological deficit; inflammation; oxidative stress; poor prognosis; subarachnoid hemorrhage.

Publication types

Review