Human autophagy measurement: an underappreciated barrier to translation

Timothy J Sargeant; Julien Bensalem

doi:10.1016/j.molmed.2021.09.003

Human autophagy measurement: an underappreciated barrier to translation

Trends Mol Med. 2021 Dec;27(12):1091-1094. doi: 10.1016/j.molmed.2021.09.003. Epub 2021 Oct 7.

Authors

Timothy J Sargeant¹, Julien Bensalem²

Affiliations

¹ Lysosomal Health in Ageing, Hopwood Centre for Neurobiology, Lifelong Health Theme, South Australian Health and Medical Research Institute (SAHMRI), Adelaide, SA, Australia. Electronic address: Tim.Sargeant@sahmri.com.
² Lysosomal Health in Ageing, Hopwood Centre for Neurobiology, Lifelong Health Theme, South Australian Health and Medical Research Institute (SAHMRI), Adelaide, SA, Australia.

PMID: 34629294
DOI: 10.1016/j.molmed.2021.09.003

Abstract

Preclinical research shows that autophagy is a modifiable process that holds promise for preventing human age-related disease. However, this knowledge has not been clinically translated. Here, we discuss recent developments in the ability to measure human autophagy, and why it is a critical step for translation.

Keywords: ageing; autophagic flux; autophagy; blood; human; translation.

MeSH terms

Autophagy*
Humans