Small molecule compounds with good anti-inflammatory activity reported in the literature from 01/2009 to 05/2021: a review

Ming Bian; Qian-Qian Ma; Yun Wu; Huan-Huan Du; Gong Guo-Hua

doi:10.1080/14756366.2021.1984903

Small molecule compounds with good anti-inflammatory activity reported in the literature from 01/2009 to 05/2021: a review

J Enzyme Inhib Med Chem. 2021 Dec;36(1):2139-2159. doi: 10.1080/14756366.2021.1984903.

Authors

Ming Bian^{1

2}, Qian-Qian Ma^{1

2}, Yun Wu³, Huan-Huan Du^{1

2}, Gong Guo-Hua^{1

2

3}

Affiliations

¹ Inner Mongolia Key Laboratory of Mongolian Medicine Pharmacology for Cardio-Cerebral Vascular System, Inner Mongolia, China.
² Institute of Pharmaceutical Chemistry and Pharmacology, Inner Mongolia Minzu University, Tongliao, Inner Mongolia, China.
³ First Clinical Medical of Inner, Mongolia Minzu University, Tongliao, Inner Mongolia, China.

Abstract

Inflammation and disease are closely related. Inflammation can induce various diseases, and diseases can promote inflammatory response, and two possibly induces each other in a bidirectional loop. Inflammation is usually treated using synthetic anti-inflammatory drugs which are associated with several adverse effects hence are not safe for long-term use. Therefore, there is need for anti-inflammatory drugs which are not only effective but also safe. Several researchers have devoted to the research and development of effective anti-inflammatory drugs with little or no side effects. In this review, we studied some small molecules with reported anti-inflammatory activities and hence potential sources of anti-inflammatory agents. The information was retrieved from relevant studies published between January 2019 and May, 2021 for review. This review study was aimed to provide relevant information towards the design and development of effective and safe anti-inflammation agents.

Keywords: Anti-inflammatory; biological activity; structure–activity relationship; synthesis.

Publication types

Review

MeSH terms

Anti-Inflammatory Agents, Non-Steroidal / chemical synthesis
Anti-Inflammatory Agents, Non-Steroidal / chemistry
Anti-Inflammatory Agents, Non-Steroidal / therapeutic use*
Humans
Inflammation / drug therapy*
Molecular Structure
Small Molecule Libraries / chemical synthesis
Small Molecule Libraries / chemistry
Small Molecule Libraries / therapeutic use*

Substances

Anti-Inflammatory Agents, Non-Steroidal
Small Molecule Libraries

Grants and funding

This work was supported by the National Natural Science Funding of China [No. 81860798] and the Science and Technology Planning Project of Inner Mongolia Autonomous Region [No. 2020SGG3689].