Tumor immunotherapy is a new therapy which developed in recent years, it has greatly changed the therapeutic schedules and brought new options for patients. However, not all patients can have obvious therapeutic effects after using immunotherapy. So selecting more suitable patients and raising immunotherapy effect are worthy to discuss. With the research of circular RNAs (circRNAs), circRNAs have been found that they not only play a significant role in the field of tumor markers, tumor progression and prognosis, but also can abnormally express in a variety of tumors and affect tumor immunity. Therefore, the circRNAs expression may not only can be used as a supplementary method for selecting patients, but also can be used to predict the efficacy of tumor immunotherapy. In this article, we summarize current knowledge on circRNAs abnormally expressed in many cancers, especially lung cancer which can affect tumor immunity, and discuss its potential effects in tumor immunotherapy, and we hope to provide more references for the clinical practice of circRNAs. .
【中文题目：环状RNA在肿瘤免疫治疗中的研究进展】 【中文摘要：肿瘤免疫治疗是近年来发展起来的全新治疗方法，极大地改变了癌症的治疗方案，为癌症患者带来了新的选择，但并不是所有患者在应用免疫治疗后都疗效明显，因此如何更加有效地选择适用免疫治疗的患者和提高免疫治疗疗效是十分值得探讨的问题。随着对环状RNA（circular RNAs, circRNAs）不断深入研究发现，circRNA不仅在肿瘤标志物、肿瘤进展和预后领域中作用显著，还可以在多种肿瘤中异常表达，进而通过多种途径影响肿瘤免疫。因此检测circRNA的表达量不仅可能作为筛选适用免疫治疗的患者的补充手段，还可能用于预测肿瘤免疫治疗的疗效。本文总结了circRNA在以肺癌为首的多种肿瘤免疫治疗中的研究进展，并讨论了其在肿瘤免疫治疗中潜在的作用，意在为circRNA的临床应用提供参考。 】 【中文关键词：环状RNA；肿瘤；肺肿瘤；肿瘤免疫治疗；免疫检查点】.
Keywords: Circular RNAs; Immune checkpoint; Lung neoplasms; Tumor; Tumor immunotherapy.