The aim of the study is to determine the effectiveness of the hypoxic training on microcirculation and the duration of preservation of the therapeutic effect in elderly patients with chronic obstructive pulmonary disease. 47 patients with COPD at the age of 60-74 years were examined. All examined patients with COPD were divided into two groups: the main group (29 people), which received real hypoxic training, and the control group (18 people), which received simulated training. The state of cutaneous microcirculation and endothelial function were evaluated using a sample with reactive hyperemia. The studies were performed in the initial state (before training), immediately after, one month and three months after the course application of training. Due to hypoxic training in elderly patients with COPD, microcirculation and endothelial function improved, which persisted for a month. A correlation was established between increased blood saturation and improved microcirculation and endothelial function both immediately and a month after the application of hypoxic training in elderly patients with COPD. The state of microcirculation and endothelial function in patients with COPD did not depend on their resistance to hypoxia. But resistance to hypoxia determined the effectiveness of the effects of hypoxic training. In patients with reduced resistance to hypoxia, the therapeutic effect of hypoxic training was less significant and short-lived compared.