Longitudinally extensive transverse myelitis with anti-myelin oligodendrocyte glycoprotein antibodies following SARS-CoV-2 infection

J Neuroimmunol. 2021 Dec 15:361:577739. doi: 10.1016/j.jneuroim.2021.577739. Epub 2021 Oct 5.

Abstract

We report the case of a patient with symptoms of myelopathy following acute SARS-CoV-2 infection. MRI documented a longitudinally extensive transverse myelitis and further investigation was unremarkable with the exception of positivity for MOG-IgG in serum. This report extends the spectrum of post-COVID-19 neurological syndromes, and documents a very significant improvement to long-term oral corticosteroid therapy in this setting. Further prospective studies are needed to establish the risk of recurrence in this subset of patients.

Keywords: COVID-19; MOG-IgG; Myelitis; Post-infectious myelitis; SARS-CoV-2.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Autoantibodies / immunology*
  • Autoantigens / immunology
  • COVID-19 / complications*
  • COVID-19 / immunology
  • Humans
  • Male
  • Myelin-Oligodendrocyte Glycoprotein / immunology*
  • Myelitis, Transverse / immunology
  • Myelitis, Transverse / pathology
  • Myelitis, Transverse / virology*
  • SARS-CoV-2

Substances

  • Autoantibodies
  • Autoantigens
  • MOG protein, human
  • Myelin-Oligodendrocyte Glycoprotein