A systematic review of primary gastric diffuse large B-cell lymphoma: Clinical diagnosis, staging, treatment and prognostic factors

Leuk Res. 2021 Dec:111:106716. doi: 10.1016/j.leukres.2021.106716. Epub 2021 Oct 1.

Abstract

Primary gastric lymphoma (PGL) is a rare clinical entity accounting for the majority of extra-nodal non-Hodgkin lymphoma (EN-NHL). The most common histological subtype is the primary gastric diffuse large B-cell lymphoma (PG-DLBCL) with a media age of 50-60 years old, mostly in male. Pathogenesis is often related to some bacterial infection such as Helicobacter pylori (H. pylori) infection. However, due to various available staging system, there is still no consensus on the staging of PG-DLBCL. The international prognostic index (IPI) is the most valuable used for the stratification of almost all subtype of NHL and as well as for PG-DLBCL. As for treatment strategies, surgery, chemotherapy, radiation therapy and antibiotic therapy in various combinations have been applied in clinical treatment. There are a few well-known prognostic factors and some of them may constitute prognostic models. Due to the increasing incidence of this neoplasm, it is necessary for clinicians to make deep insight of the diagnosis, staging, treatment and prognostic factors of PG-DLBCL.

Keywords: Diagnosis; Primary gastric diffuse large B-cell lymphoma; Prognostic factor; Stage; Treatment.

Publication types

  • Systematic Review

MeSH terms

  • Humans
  • Lymphoma, Large B-Cell, Diffuse / classification
  • Lymphoma, Large B-Cell, Diffuse / diagnosis*
  • Lymphoma, Large B-Cell, Diffuse / therapy*
  • Lymphoma, Non-Hodgkin / classification
  • Lymphoma, Non-Hodgkin / diagnosis*
  • Lymphoma, Non-Hodgkin / therapy*
  • Neoplasm Staging
  • Stomach Neoplasms / classification
  • Stomach Neoplasms / diagnosis*
  • Stomach Neoplasms / therapy*

Supplementary concepts

  • Familial primary gastric lymphoma