Abstract
There is inadequate screening for SARS-COV-2 during pregnancy. We aimed to determine the impact of maternal and neonatal cord blood SARS-COV-2 antibodies and placental transfer ratios in a region with a low screening plan. We performed a blind study in one of the SARS-CoV-2 epicenters in South America. 32% of pregnant women were serological positive. Importantly, there is an efficient passive immunization of the fetus to SARS-CoV-2. We report high incidence of SARS-CoV-2 infection during pregnancy, which is higher than officially reported. Therefore the need of active immunization to enhance maternal protection and fetal passive immunization.
Keywords:
IgG; IgM; Placenta; Pregnancy; SARS-COV-2.
Copyright © 2021 Elsevier Ltd. All rights reserved.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Adolescent
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Adult
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Antibodies, Viral / blood
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COVID-19 / blood
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COVID-19 / epidemiology*
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COVID-19 / immunology
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Ecuador / epidemiology
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Female
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Fetal Blood / immunology*
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Fetal Blood / metabolism
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Humans
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Immunization, Passive / statistics & numerical data
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Immunoglobulin G / blood
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Immunoglobulin M / blood
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Incidence
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Infant, Newborn
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Infectious Disease Transmission, Vertical / statistics & numerical data
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Male
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Middle Aged
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Pregnancy
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Pregnancy Complications, Infectious / blood
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Pregnancy Complications, Infectious / epidemiology*
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Pregnancy Complications, Infectious / immunology
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SARS-CoV-2 / immunology*
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Seroepidemiologic Studies
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Young Adult
Substances
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Antibodies, Viral
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Immunoglobulin G
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Immunoglobulin M