Methicillin and multidrug resistant pathogenic Staphylococcus aureus associated sepsis in hospitalized neonatal infections and antibiotic susceptibility

Khaloud M Alarjani; Abeer M Almutairi; Fatmah S AlQahtany; Ilavenil Soundharrajan

doi:10.1016/j.jiph.2021.08.031

Methicillin and multidrug resistant pathogenic Staphylococcus aureus associated sepsis in hospitalized neonatal infections and antibiotic susceptibility

J Infect Public Health. 2021 Nov;14(11):1630-1634. doi: 10.1016/j.jiph.2021.08.031. Epub 2021 Aug 28.

Authors

Khaloud M Alarjani¹, Abeer M Almutairi², Fatmah S AlQahtany³, Ilavenil Soundharrajan⁴

Affiliations

¹ Department of Botany and Microbiology, College of Science, King Saud University, Riyadh 11451, Saudi Arabia.
² Science Department, College of Basic Education, Public Authority for Applied Education and Training, (PAAET), Alardyia, Kuwait.
³ Department of Pathology, Hematopathology Unit, College of Medicine, King Saud University, Medical City, King Saud University, Riyadh 24251, Saudi Arabia.
⁴ Grassland and Forage Division, National Institute of Animal Science, RDA, Seonghwan-Eup, Cheonan-Si, Chungnam, 330-801, Republic of Korea. Electronic address: ilavenil@korea.kr.

PMID: 34624718
DOI: 10.1016/j.jiph.2021.08.031

Abstract

Background: Neonatal infection is infection of the newborn or neonate acquired in first four weeks of life or during prenatal development. Microorganism associated neonatal infections caused severe mortality in recent years. It is developed either prenatally or within 28 days of neonatal period. This infection is mainly transmitted from mother to child through placenta. It has been well associated with the premature rupture of membranes which markedly enhances the risk of neonatal sepsis.

Methods: The present experiment was designed to analyze bacteria, their antibiotic resistance pattern and possible risk factors among neonatal patients with sepsis. The neonates specimen was subjected for the isolation of bacteria and antibiotic susceptibility test. Neonates were analyzed with previous clinical history such as, previous admission in hospitals, mode of delivery, birth weight, and feeding type in accordance with questionnaire.

Results: Gram-positive bacteria isolates were found to be high (79 strains, 64.22%) than the Gram-negative bacteria (44 strains, 32.5%). Staphylococcus aureus (33 strains, 26.9%) was the major Gram-positive groups of bacteria. Multidrug resistance analysis accounted more S. aureus (26.9%) and 5 strains (15.15%) showed methicillin resistance, whereas 84.9% were found to be sensitive to methicillin.

Conclusion: In this study, S. aureus and K. pneumoniae were the highest frequency of isolates. The overall percentage of multidrug resistant isolates was high in this study. Highest degree of resistance was observed in ampicillin against all isolates. Hence much attention is required while diagnosing sepsis among neonates. To analyze the risk for neonatal sepsis, it is not preferable for caesarian mode of delivery. Moreover, frequent screening of mother, suitable prenatal care of newborns with proper clinical interventions isthe key elements to control sepsis.

Keywords: Bacteria; Drug resistant; Methicillin resistance; Neonatal sepsis; Pathogens.

MeSH terms

Anti-Bacterial Agents / pharmacology
Anti-Bacterial Agents / therapeutic use
Drug Resistance, Bacterial
Female
Humans
Infant, Newborn
Infectious Disease Transmission, Vertical
Methicillin
Microbial Sensitivity Tests
Pregnancy
Sepsis* / epidemiology
Staphylococcus aureus*

Substances

Anti-Bacterial Agents
Methicillin