Searching for methyllysine-binding aromatic cages

Biochem J. 2021 Oct 15;478(19):3613-3619. doi: 10.1042/BCJ20210106.

Abstract

Methylation of lysine residues plays crucial roles in a wide variety of cell signaling processes. While the biological importance of recognition of methylated histones by reader domains in the cell nucleus is well established, the processes associated with methylation of non-histone proteins, particularly in the cytoplasm of the cell, are not well understood. Here, we describe a search for potential methyllysine readers using a rapid structural motif-mining algorithm Erebus, the PDB database, and knowledge of the methyllysine binding mechanisms.

Keywords: aromatic cage; binding; methylation; structure.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Algorithms
  • Cytosol / metabolism
  • Databases, Protein
  • Epigenesis, Genetic
  • Histones / chemistry*
  • Histones / metabolism*
  • Humans
  • Lysine / metabolism*
  • Methylation
  • Models, Molecular
  • Protein Binding
  • Protein Domains*
  • Protein Processing, Post-Translational

Substances

  • Histones
  • Lysine