Clinical stages of recurrent hepatocellular carcinoma: A retrospective cohort study

Si-Yang Yao; Bin Liang; Yuan-Yuan Chen; Yun-Tian Tang; Xiao-Feng Dong; Tian-Qi Liu

doi:10.12998/wjcc.v9.i27.8020

Clinical stages of recurrent hepatocellular carcinoma: A retrospective cohort study

World J Clin Cases. 2021 Sep 26;9(27):8020-8026. doi: 10.12998/wjcc.v9.i27.8020.

Authors

Si-Yang Yao¹, Bin Liang¹, Yuan-Yuan Chen¹, Yun-Tian Tang¹, Xiao-Feng Dong¹, Tian-Qi Liu²

Affiliations

¹ Department of Hepatobiliary-Pancreatic-Splenic Surgery, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021, Guangxi Zhuang Autonomous Region, China.
² Department of Hepatobiliary-Pancreatic-Splenic Surgery, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021, Guangxi Zhuang Autonomous Region, China. gxljrqt@163.com.

Abstract

Background: Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related death worldwide, and has relatively high recurrence rates. Few studies have been published on the clinical stages of recurrent HCC.

Aim: To assess the applicability of the Barcelona Clinic Liver Cancer (BCLC) staging for recurrent HCC and the need to establish clinical stage criteria for recurrent HCC.

Methods: The clinicopathological data of 81 patients with recurrent HCC who were admitted to the Hospital of Guangxi Zhuang Autonomous Region from January 2013 to December 2017 were collected. The patients were divided into three groups according to the BCLC staging system as follows: (1) Group A with BCLC stage A, 51 patients; (2) Group B with BCLC stage B, 14 patients; and (3) Group C with BCLC stage C, 16 patients. The median time to tumor recurrence and the median overall survival were compared.

Results: The median time to tumor recurrence in groups A, B, and C was 16 ± 1.5 mo, 10 ± 2.8 mo, and 6 ± 0.5 mo, respectively, with a statistically significant difference among them (χ ² = 70.144, P < 0.05); no statistically significant difference was noted between group A and group B (χ ² = 2.659, P > 0.05), although there were statistically significant differences between group A and group C and between group B and group C (χ ² = 62.110, and 19.972, P < 0.05). The median overall survival in groups A, B, and C were 42 ± 5.1 mo, 22 ± 3.1 mo, and 13 ± 1.8 mo, respectively, with a statistically significant difference among them (χ ² = 38.949, P < 0.05); there were statistically significant differences between group A and group B, group A and group C, and group B and group C (χ ² = 9.577, 37.172, and 7.183, respectively; P < 0.05).

Conclusion: There are different prognoses in recurrent HCC patients according to the BCLC staging. Therefore, BCLC staging is applicable to recurrent HCC and it is essential to formulate clinical stage criteria for recurrent HCC.

Keywords: Barcelona Clinic Liver Cancer staging system; Clinical stages; Recurrent hepatocellular carcinoma.