Comparison of the Incidence of Cardiovascular Diseases in Weight Groups with Healthy and Unhealthy Metabolism

Wenqiang Wang; Jia He; Yunhua Hu; Yanpeng Song; Xianghui Zhang; Heng Guo; Xinping Wang; Mulatibieke Keerman; Jiaolong Ma; Yizhong Yan; Jingyu Zhang; Rulin Ma; Shuxia Guo

doi:10.2147/DMSO.S330212

Comparison of the Incidence of Cardiovascular Diseases in Weight Groups with Healthy and Unhealthy Metabolism

Diabetes Metab Syndr Obes. 2021 Oct 1:14:4155-4163. doi: 10.2147/DMSO.S330212. eCollection 2021.

Authors

Wenqiang Wang^#¹, Jia He^#¹, Yunhua Hu¹, Yanpeng Song², Xianghui Zhang¹, Heng Guo¹, Xinping Wang¹, Mulatibieke Keerman¹, Jiaolong Ma¹, Yizhong Yan¹, Jingyu Zhang¹, Rulin Ma¹, Shuxia Guo^{1

3}

Affiliations

¹ Department of Public Health, Shihezi University School of Medicine, Shihezi, Xinjiang, People's Republic of China.
² Department of Social Work, The First Affiliated Hospital of Shihezi University Medical College, Shihezi, Xinjiang, People's Republic of China.
³ Department of NHC Key Laboratory of Prevention and Treatment of Central Asia High Incidence Diseases, The First Affiliated Hospital of Shihezi University Medical College, Shihezi, Xinjiang, People's Republic of China.

^# Contributed equally.

Abstract

Background: We aimed to identify the relationship between metabolically healthy obesity (MHO), a special subtype of obesity, and the incidence of cardiovascular disease (CVD) in rural Xinjiang.

Methods: Body mass index (BMI) and the Joint Interim Statement criteria were utilized to define obesity and metabolic status, respectively. A baseline survey was conducted between 2010 and 2012. The cohort was followed-up until 2017, including 5059 participants (2953 Uyghurs and 2106 Kazakhs) in the analysis.

Results: During 6.78 years of follow-up, 471 individuals developed CVD, 10.8% (n=545) of whom were obese, and the prevalence of MHO and MHNW was 5.2% and 54.5%, respectively. Compared with metabolically healthy normal weight subjects, the subjects with MHO had an increased risk of CVD (hazard ratio [HR]=1.76, 95% confidence interval [CI]: 1.23-2.51), while the metabolically unhealthy obesity (MUO) group had an even higher risk (HR=3.80, 95% CI: 2.87-5.03). Additionally, there were sex differences in the relationship between BMI-metabolic status and incident CVD (P _interaction =0.027). Compared with the subjects with MHO, those with MUO had an increased risk of CVD (HR=1.84, 95% CI: 1.26-2.71).

Conclusion: MHO was associated with a high risk of CVD among adults in rural Xinjiang. In each BMI category, metabolically unhealthy subjects had a higher risk of developing CVD than did metabolically healthy subjects.

Keywords: cardiovascular disease; epidemiology; metabolically healthy obesity; rural areas.

Grants and funding

This research was funded by the National Natural Science Foundation of China (No. 81560551), the Shihezi University Innovation Outstanding Young Talents Program (Natural Science) (No. CXPY202004) and the Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences (2020-PT330-003).