Angioedema of the tongue due to haloperidol

Abstract

Background: Angioedema is an allergic reaction that has rarely been associated with haloperidol. There are 3 case reports in the literature, including one involving a child. Angioedema is mediated by increased capillary permeability and plasma extravasation, either related to histamine/IgE or bradykinin. When triggered by a medication, it typically presents within a few hours of medication administration. Histamine-mediated angioedema is generally treated with corticosteroids, antihistamines, and/or epinephrine.

Case presentation: We review a case of angioedema of the tongue in an adolescent, thought to be triggered by haloperidol. Initial treatment was targeted toward a presumed dystonic reaction. Telephone consent was obtained from the patient's mother to publish this report.

Conclusions: Clinicians should be aware of potential dangerous adverse effects of commonly used medications. Patients with angioedema may need to be monitored for up to 36 h.

Keywords: Adolescent; Angioedema; Emergency psychiatry; Haloperidol.