Rare Lelliottia nimipressuralis from a wound infection case report using whole genome sequencing-based bacterial identification

Diagn Microbiol Infect Dis. 2021 Dec;101(4):115538. doi: 10.1016/j.diagmicrobio.2021.115538. Epub 2021 Sep 10.

Abstract

Identification of clinical bacterial isolates is an essential first step to provide guidelines for treatment of pathogenic bacterial infection. Infection occurred in a laceration along the medial aspect of left upper arm of a 71-year-old female. Conventional biochemical testing and MALDI-TOF MS identification failed to correctly identify a bacterial isolate. Using whole genome sequencing, the isolate was identified as Lelliottia nimipressuralis. WGS can overcome the limitations of conventional phenotypic and molecular identification methods and successfully identified a rare pathogen. This case is the first report of a human infection of L. nimipressuralis.

Keywords: Bacterial identification; Lelliottia nimipressuralis; Whole genome sequencing.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Anti-Bacterial Agents / pharmacology
  • Anti-Bacterial Agents / therapeutic use
  • Enterobacteriaceae / drug effects
  • Enterobacteriaceae / genetics
  • Enterobacteriaceae / isolation & purification*
  • Enterobacteriaceae Infections / diagnosis*
  • Enterobacteriaceae Infections / microbiology
  • Enterobacteriaceae Infections / therapy
  • Female
  • Genome, Bacterial / genetics
  • Humans
  • Microbial Sensitivity Tests
  • Molecular Typing*
  • Treatment Outcome
  • Whole Genome Sequencing*
  • Wound Infection / diagnosis*
  • Wound Infection / microbiology
  • Wound Infection / therapy

Substances

  • Anti-Bacterial Agents

Supplementary concepts

  • Lelliottia nimipressuralis