Rnf43 is "lord of the ring" finger proteins in remyelination

Debosmita Sardar; Benjamin Deneen

doi:10.1016/j.neuron.2021.09.012

Rnf43 is "lord of the ring" finger proteins in remyelination

Neuron. 2021 Oct 6;109(19):3069-3071. doi: 10.1016/j.neuron.2021.09.012.

Authors

Debosmita Sardar¹, Benjamin Deneen²

Affiliations

¹ Center for Cell and Gene Therapy, Stem Cells and Regenerative Medicine Center, Baylor College of Medicine, Houston, TX 77030, USA.
² Center for Cell and Gene Therapy, Stem Cells and Regenerative Medicine Center, Baylor College of Medicine, Houston, TX 77030, USA; Department of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA; Department of Neurosurgery, Baylor College of Medicine, Houston, TX 77030, USA. Electronic address: deneen@bcm.edu.

PMID: 34619086
DOI: 10.1016/j.neuron.2021.09.012

Abstract

Oligodendrocyte precursor cell differentiation into myelinating oligodendrocytes is critical for remyelination in the central nervous system after injury. In this issue of Neuron, Niu et al. (2021) detail a novel role for ring finger protein Rnf43, which is expressed in response to injury and is essential to promote remyelination in vivo.

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MeSH terms

Cell Differentiation
Central Nervous System
Oligodendrocyte Precursor Cells*
Oligodendroglia
Remyelination*