Effect of a Synthetic Organoselenium Compound on Post-Vaccination Immunopoiesis in the Red Bone Marrow and Cell Composition of Peripheral Blood of White Mice Vaccinated with Yersinia pestis EV

V I Dubrovina; T P Starovoitova; O V Yur'eva; A B Pyatidesyatnikova; V A Potapov; M V Musalov; S V Balakhonov

doi:10.1007/s10517-021-05287-0

Effect of a Synthetic Organoselenium Compound on Post-Vaccination Immunopoiesis in the Red Bone Marrow and Cell Composition of Peripheral Blood of White Mice Vaccinated with Yersinia pestis EV

Bull Exp Biol Med. 2021 Sep;171(5):651-655. doi: 10.1007/s10517-021-05287-0. Epub 2021 Oct 7.

Authors

V I Dubrovina¹, T P Starovoitova², O V Yur'eva², A B Pyatidesyatnikova², V A Potapov³, M V Musalov³, S V Balakhonov²

Affiliations

¹ Irkutsk Antiplague Research Institute, Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, Irkutsk, Russia. dubrovina-valya@mail.ru.
² Irkutsk Antiplague Research Institute, Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, Irkutsk, Russia.
³ A. E. Favorsky Irkutsk Institute of Chemistry, Siberian Division of the Russian Academy of Sciences, Irkutsk, Russia.

PMID: 34618261
DOI: 10.1007/s10517-021-05287-0

Abstract

We studied the effect of an experimental synthetic organoselenium compound 2,6-dipyridinium- 9-selenabicyclo[3.3.1]nonane dibromide (974zh) on the cell composition of the red bone marrow and peripheral blood in white mice. The study drug co-administered with Yersinia pestis EV vaccine strain (103 CFU) potentiated maturation and migration of mature neutrophils from the bone marrow into the circulation. Reducing the dose of the live vaccine and the anti-inflammatory properties of the study drug made it possible to reduce the allergic reaction during the vaccination process.

Keywords: Yersinia pestis EV; immunopoiesis; organoselenium; selenium.

MeSH terms

Animals
Animals, Outbred Strains
Blood Cell Count
Blood Cells / drug effects
Blood Cells / immunology
Blood Cells / pathology
Bone Marrow / drug effects
Bone Marrow / immunology
Lymphopoiesis / drug effects*
Mice
Organoselenium Compounds / pharmacology*
Vaccination*
Vaccines, Attenuated / immunology
Vaccines, Attenuated / pharmacology*
Vaccines, Attenuated / therapeutic use
Yersinia pestis / immunology*

Substances

Organoselenium Compounds
Vaccines, Attenuated