Enzyme Therapeutic for Ischemia and Reperfusion Injury in Organ Transplantation

Ran Yan; Jie Ren; Jing Wen; Zheng Cao; Di Wu; Meng Qin; Duo Xu; Roxanne Castillo; Feifei Li; Fang Wang; Zhihua Gan; Chaoyong Liu; Ping Wei; Yunfeng Lu

doi:10.1002/adma.202105670

Enzyme Therapeutic for Ischemia and Reperfusion Injury in Organ Transplantation

Adv Mater. 2022 Jan;34(1):e2105670. doi: 10.1002/adma.202105670. Epub 2021 Nov 6.

Authors

Ran Yan^{1

2}, Jie Ren², Jing Wen³, Zheng Cao², Di Wu², Meng Qin⁴, Duo Xu², Roxanne Castillo², Feifei Li⁴, Fang Wang⁴, Zhihua Gan⁴, Chaoyong Liu⁴, Ping Wei¹, Yunfeng Lu²

Affiliations

¹ College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing, 211816, China.
² Department of Chemical and Biomolecular Engineering, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
³ Department of Microbiology, Immunology and Molecular Genetics, David Geffen School of Medicine, UCLA AIDS Institute, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
⁴ Beijing Advanced Innovation Center for Soft Matter Science and Engineering, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing, 100029, China.

PMID: 34617335
DOI: 10.1002/adma.202105670

Abstract

Ischemia-reperfusion injury (IRI) remains as a critical challenge for organ transplantation. Herein, an enzyme therapeutic based on superoxide dismutase and catalase for effective mitigation of IRI and pathogen-induced liver injury is reported, providing a therapeutic for organ transplantation and other diseases.

Keywords: antioxidants; enzyme therapeutics; ischemia-reperfusion injuries; organ transplantation; reactive oxygen species.

MeSH terms

Humans
Ischemia
Organ Transplantation*
Reactive Oxygen Species / therapeutic use
Reperfusion Injury*
Superoxide Dismutase

Substances

Reactive Oxygen Species
Superoxide Dismutase