Analysis of Morphological Changes in the CNS and Internal Organs of Macaca mulatta Monkeys after Intracerebral Injection of a Low-Attenuated Rubella Virus Strain

O A Shamsutdinova; D V Bulgin; D D Karal-Ogly; I N Lavrent'eva

doi:10.1007/s10517-021-05291-4

Analysis of Morphological Changes in the CNS and Internal Organs of Macaca mulatta Monkeys after Intracerebral Injection of a Low-Attenuated Rubella Virus Strain

Bull Exp Biol Med. 2021 Sep;171(5):671-675. doi: 10.1007/s10517-021-05291-4. Epub 2021 Oct 7.

Authors

O A Shamsutdinova¹, D V Bulgin², D D Karal-Ogly², I N Lavrent'eva³

Affiliations

¹ Research Institute of Medical Primatology, Sochi, Russia. shamsutdinovao-a@yandex.ru.
² Research Institute of Medical Primatology, Sochi, Russia.
³ Pasteur St. Petersburg Research Institute of Epidemiology and Microbiology, St. Petersburg, Russia.

PMID: 34617176
DOI: 10.1007/s10517-021-05291-4

Abstract

We studied the localization and severity of morphological changes in CNS and internal organs of animals intacerebrally infected with a low-attenuated rubella virus strain "Orlov-14". The data obtained can be used as morphological criteria reflecting low level of attenuation of rubella virus strains to improve the control of the safety of attenuated strains of live rubella vaccines.

Keywords: Macaca mulatta monkeys; attenuation; intracerebral inoculation; rubella virus.

MeSH terms

Animal Structures / pathology*
Animal Structures / virology
Animals
Blood-Brain Barrier / pathology
Blood-Brain Barrier / virology
Cells, Cultured
Central Nervous System / pathology*
Central Nervous System / virology*
Child
Humans
Injections, Intraventricular
Macaca mulatta
Rabbits
Random Allocation
Rubella / cerebrospinal fluid
Rubella / pathology
Rubella / virology
Rubella virus / immunology*
Rubella virus / physiology
Vaccines, Attenuated / administration & dosage*
Vaccines, Attenuated / adverse effects
Viral Load
Virus Activation / physiology

Substances

Vaccines, Attenuated