Non-coding RNAs in Regulating Tumor Angiogenesis

Xin Song; Yanan Guo; Peng Song; Dongzhu Duan; Wenjing Guo

doi:10.3389/fcell.2021.751578

Non-coding RNAs in Regulating Tumor Angiogenesis

Front Cell Dev Biol. 2021 Sep 20:9:751578. doi: 10.3389/fcell.2021.751578. eCollection 2021.

Authors

Xin Song¹, Yanan Guo², Peng Song^{3

4}, Dongzhu Duan⁵, Wenjing Guo²

Affiliations

¹ School of Life Sciences and Engineering, Lanzhou University of Technology, Lanzhou, China.
² School of Traditional Chinese and Western Medicine, Gansu University of Traditional Chinese Medicine, Lanzhou, China.
³ Affiliated Hospital of Gansu University of Chinese Medicine, Lanzhou, China.
⁴ Key Laboratory of Prevention and Treatment for Chronic Diseases by TCM, Lanzhou, China.
⁵ Shaanxi Key Laboratory of Phytochemistry and College of Chemistry and Chemical Engineering, Baoji University of Arts and Sciences, Baoji, China.

Abstract

Non-coding RNAs (ncRNAs) are RNAs that do not encode proteins, but perform biological functions in various physiological and pathological processes, including cancer formation, inflammation, and neurological diseases. Tumor blood vessels are a key target for cancer management. A number of factors regulate the angiogenesis of malignant tumors. NcRNAs participate in the regulation of tumor angiogenesis. Abnormal expression of ncRNAs act as tumor suppressors or oncogenes to affect the development of tumors. In this review we summarized the biological functions of ncRNAs, and discussed its regulatory mechanisms in tumor angiogenesis. This article will provide new insights for the research of ncRNAs in tumor angiogenesis.

Keywords: biological function; molecular mechanism; ncRNA; tumor angiogenesis; tumor metabolism.

Publication types

Review