IL-13 Derived Type 2 Innate Lymphocytes Ameliorates Cardiomyocyte Apoptosis Through STAT3 Signaling Pathway

Ting Hong; Saiqi Li; Xiaoyu Guo; Yazhong Wei; Jingjing Zhang; Xiaohui Su; Miao Zhou; Haizhen Jin; Qing Miao; Lei Shen; Minfang Zhu; Bin He

doi:10.3389/fcell.2021.742662

IL-13 Derived Type 2 Innate Lymphocytes Ameliorates Cardiomyocyte Apoptosis Through STAT3 Signaling Pathway

Front Cell Dev Biol. 2021 Sep 20:9:742662. doi: 10.3389/fcell.2021.742662. eCollection 2021.

Authors

Ting Hong¹, Saiqi Li¹, Xiaoyu Guo¹, Yazhong Wei¹, Jingjing Zhang², Xiaohui Su², Miao Zhou³, Haizhen Jin⁴, Qing Miao⁵, Lei Shen², Minfang Zhu¹, Bin He¹

Affiliations

¹ Department of Critical Care Medicine, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China.
² Shanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
³ Department of Anesthesiology and Surgical Intensive Care Unit, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
⁴ Central Laboratory, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China.
⁵ Departments of Anesthesiology, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China.

Abstract

The involvement of cardiomyopathy during sepsis means higher mortality and prolonged length of hospital stay. Many efforts have been made to alleviate the apoptosis of cardiomyocytes in sepsis. The huge potential of IL-13 in tissue repair has attracted increasing attention. In the present study, we used LPS-treated mice or primary cardiomyocytes as a sepsis model to explore the anti-apoptotic ability of IL-13. It was found that an increased level of exogenous IL-13 was beneficial to the recovery of heart function in sepsis, and this anti-apoptotic effect of IL-13 was probably through enhancing the phosphorylation of STAT3 Ser727. In addition, we identified that the heart protective effect of IL-13 was associated with type 2 innate lymphocytes (ILC2). All these findings may provide a potential promising treatment for sepsis-induced cardiomyopathy.

Keywords: IL-13; ILC2; cardiomyocyte apoptosis; sepsis; stat3.