Advances in Chromodomain Helicase DNA-Binding (CHD) Proteins Regulating Stem Cell Differentiation and Human Diseases

Caojie Liu; Ning Kang; Yuchen Guo; Ping Gong

doi:10.3389/fcell.2021.710203

Advances in Chromodomain Helicase DNA-Binding (CHD) Proteins Regulating Stem Cell Differentiation and Human Diseases

Front Cell Dev Biol. 2021 Sep 20:9:710203. doi: 10.3389/fcell.2021.710203. eCollection 2021.

Authors

Caojie Liu¹, Ning Kang¹, Yuchen Guo¹, Ping Gong¹

Affiliation

¹ State Key Laboratory of Oral Diseases, West China School of Stomatology, Sichuan University, Chengdu, China.

Abstract

Background: Regulation of gene expression is critical for stem cell differentiation, tissue development, and human health maintenance. Recently, epigenetic modifications of histone and chromatin remodeling have been verified as key controllers of gene expression and human diseases. Objective: In this study, we review the role of chromodomain helicase DNA-binding (CHD) proteins in stem cell differentiation, cell fate decision, and several known human developmental disorders and cancers. Conclusion: CHD proteins play a crucial role in stem cell differentiation and human diseases.

Keywords: CHARGE syndrome; chromatin remodeling; chromodomain helicase DNA-binding protein; epigenetic; histone modification.

Publication types

Review