One-pot three-component tandem annulation of 4-hydroxycoumarine with aldehyde and aromatic amines using graphene oxide as an efficient catalyst

Rabindranath Singha; Aminul Islam; Pranab Ghosh

doi:10.1038/s41598-021-99360-3

One-pot three-component tandem annulation of 4-hydroxycoumarine with aldehyde and aromatic amines using graphene oxide as an efficient catalyst

Sci Rep. 2021 Oct 6;11(1):19891. doi: 10.1038/s41598-021-99360-3.

Authors

Rabindranath Singha¹, Aminul Islam¹, Pranab Ghosh²

Affiliations

¹ Department of Chemistry, University of North Bengal, Dist-Darjeeling, West Bengal, India.
² Department of Chemistry, University of North Bengal, Dist-Darjeeling, West Bengal, India. pizy12@yahoo.com.

Abstract

A convenient and efficient solvent-free, facile, one-pot three-component graphene oxide catalysed approach has been described for the synthesis of chromeno-[4,3-b]quinolin-6-one derivatives from 4-hydroxycoumarin with aldehydes and aromatic amines. Graphene oxide (GO) has proved to be a new class of heterogeneous carbocatalyst which could be easily recovered and reused up to 5th run without significant loss of its catalytic activity. A broad scope of substrate applicability is offered and a plausible mechanism is also suggested for this developed protocol.

Publication types

Research Support, Non-U.S. Gov't