Zinc supplementation and its benefits in the management of chronic liver disease: An in-depth literature review

Ashley Bloom; Stephen Bloom; Hannah Silva; Amanda J Nicoll; Rohit Sawhney

doi:10.1016/j.aohep.2021.100549

Zinc supplementation and its benefits in the management of chronic liver disease: An in-depth literature review

Ann Hepatol. 2021 Nov-Dec:25:100549. doi: 10.1016/j.aohep.2021.100549. Epub 2021 Oct 3.

Authors

Ashley Bloom¹, Stephen Bloom², Hannah Silva³, Amanda J Nicoll³, Rohit Sawhney⁴

Affiliations

¹ Department of Gastroenterology, Eastern Health, 3 West, Building B, Box Hill Hospital, 8 Arnold Street, Box Hill, Melbourne, Victoria, Australia.
² Department of Gastroenterology, Eastern Health, 3 West, Building B, Box Hill Hospital, 8 Arnold Street, Box Hill, Melbourne, Victoria, Australia; Eastern Health Clinical School, Monash University, Melbourne, Victoria, Australia.
³ Department of Gastroenterology, Eastern Health, 3 West, Building B, Box Hill Hospital, 8 Arnold Street, Box Hill, Melbourne, Victoria, Australia; Eastern Health Clinical School, Monash University, Melbourne, Victoria, Australia; Department of Nutrition and Dietetics, Eastern Health, Melbourne, Victoria, Australia.
⁴ Department of Gastroenterology, Eastern Health, 3 West, Building B, Box Hill Hospital, 8 Arnold Street, Box Hill, Melbourne, Victoria, Australia; Eastern Health Clinical School, Monash University, Melbourne, Victoria, Australia. Electronic address: Rohit.Sawhney@easternhealth.org.au.

PMID: 34614431
DOI: 10.1016/j.aohep.2021.100549

Abstract

Malnutrition among patients with chronic liver disease (CLD) is a common complication with significant prognostic implications for patients with liver cirrhosis. Micronutrient deficiency has been associated with an increased risk of hepatic decompensation and is an independent risk factor for mortality among cirrhotic patients. Micronutrient deficiencies in patients with CLD include zinc, vitamin A, vitamin D and selenium. This review article aims to evaluate the literature to date on the complications of zinc deficiency in patients with CLD. A management algorithm for zinc replacement has also been proposed.

Keywords: Chronic liver disease; Malnutrition; Zinc.

Publication types

Review

MeSH terms

Chronic Disease
Dietary Supplements*
Humans
Liver Diseases / diagnosis
Liver Diseases / etiology
Liver Diseases / therapy*
Trace Elements / therapeutic use*
Zinc / therapeutic use*

Substances

Trace Elements
Zinc